Spider-Man’s “Brand New Day” has ended and beginning with Amazing Spider-Man #648 he is entering the “Big Time”. The new arch is written by Dan Slott with art by Humberto Ramos. Marvel Comics’ official description for the issue:

Big Time begins! Big changes are happening for the Amazing Spider-Man: Bigger threats, bigger guest-stars, and a big opportunity that could turn Peter Parker’s life around! Which cast members are staying and who’s saying goodbye? Find out as we’re introduced to new characters and reintroduced to a number of Spidey villains as they make the triumphant return to the book! Plus: New developments for Mayor J. Jonah Jameson, the staff at Front Line, and The Sinister Six! The next chapter in Spider-Man history starts here! Guest-starring The Avengers and The Fantastic Four in a giant-sized, 390page lead feature! Plus: An all-new adventure featuring the all-new Spider-Girl! Tobin and Henry bring a tale of action & intrigue, and make a strong argument for why you can sometimes send a Spider-GIRL to do a Spider-MAN’s job.